CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P00336
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P00336
LDHB_PIG
Sus scrofa
L-lactate dehydrogenase B chain

PDB Structure

PDB 5LDH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7 A resolution.
Grau, U.M., Trommer, W.E., Rossmann, M.G.
J.Mol.Biol.