CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.3.1.82
(-)-isopiperitenone reductase.
based on mapping to UniProt Q6WAU1
(+)-cis-isopulegone + NADP(+) = (-)-isopiperitenone + NADPH.
-!- The reaction occurs in the opposite direction to that shown above. -!- Participates in the menthol-biosynthesis pathway of Mentha plants. -!- (+)-pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates. -!- Has a preference for NADPH as the reductant, with NADH being a poor substitute. -!- Highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product.

UniProtKB Entries (1)

Q6WAU1
IPIPR_MENPI
Mentha x piperita
(-)-isopiperitenone reductase

PDB Structure

PDB 5LCX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases.
Lygidakis, A., Karuppiah, V., Hoeven, R., Ni Cheallaigh, A., Leys, D., Gardiner, J.M., Toogood, H.S., Scrutton, N.S.
Angew.Chem.Int.Ed.Engl.