CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Ephrin type-B receptor 2

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P54753
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P54753
EPHB3_HUMAN
Homo sapiens
Ephrin type-B receptor 3

PDB Structure

PDB 5L6P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3.
Kung, A., Chen, Y.C., Schimpl, M., Ni, F., Zhu, J., Turner, M., Molina, H., Overman, R., Zhang, C.
J.Am.Chem.Soc.