CATH Domain 5l3cA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.10	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Domain Context

CATH Clusters

Superfamily	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family	Lysine-specific histone demethylase 1A

Enzyme Information

1.-.-.-

Oxidoreductases.

based on mapping to UniProt O60341

UniProtKB Entries (1)

KDM1A_HUMAN

Homo sapiens

Lysine-specific histone demethylase 1A

PDB Structure

PDB	5L3C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors. Pilotto, S., Speranzini, V., Marabelli, C., Rusconi, F., Toffolo, E., Grillo, B., Battaglioli, E., Mattevi, A. Hum.Mol.Genet.