CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt O60674
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O60674
JAK2_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK2

PDB Structure

PDB 5L3A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors.
Ritzen, A., Srensen, M.D., Dack, K.N., Greve, D.R., Jerre, A., Carnerup, M.A., Rytved, K.A., Bagger-Bahnsen, J.
Acs Med.Chem.Lett.