CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709
FA7_HUMAN
Homo sapiens
Coagulation factor VII

PDB Structure

PDB 5L30
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Ladziata, V.U., Glunz, P.W., Zou, Y., Zhang, X., Jiang, W., Jacutin-Porte, S., Cheney, D.L., Wei, A., Luettgen, J.M., Harper, T.M., Wong, P.C., Seiffert, D., Wexler, R.R., Priestley, E.S.
Bioorg.Med.Chem.Lett.