CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Cyclin-dependent kinase 6

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q00534
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q00534
CDK6_HUMAN
Homo sapiens
Cyclin-dependent kinase 6

PDB Structure

PDB 5L2S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Chen, P., Lee, N.V., Hu, W., Xu, M., Ferre, R.A., Lam, H., Bergqvist, S., Solowiej, J., Diehl, W., He, Y.A., Yu, X., Nagata, A., VanArsdale, T., Murray, B.W.
Mol.Cancer Ther.