CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.11350 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.11350 |
| Functional Family | GDP-fucose protein O-fucosyltransferase 1 |
Enzyme Information
| 2.4.1.221 |
Peptide-O-fucosyltransferase.
based on mapping to UniProt Q91ZW2
Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.
-!- Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. -!- The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
|
UniProtKB Entries (1)
| Q91ZW2 |
OFUT1_MOUSE
Mus musculus
GDP-fucose protein O-fucosyltransferase 1
|
PDB Structure
| PDB | 5KXQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1.
Nat. Chem. Biol.
|