CATH Classification

Domain Context

CATH Clusters

Superfamily NadA-like
Functional Family

Enzyme Information

2.5.1.72
Quinolinate synthase.
based on mapping to UniProt O57767
Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate.
-!- Quinolinate synthase catalyzes the second step in the de novo biosynthesis of NAD(+) from aspartate in some bacteria, with EC 1.4.3.16 catalyzing the first step and EC 2.4.2.19 the third step. -!- In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme.

UniProtKB Entries (1)

O57767
NADA_PYRHO
Pyrococcus horikoshii OT3
Quinolinate synthase A

PDB Structure

PDB 5KTN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate.
Fenwick, M.K., Ealick, S.E.
Biochemistry