CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase iota

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4
POLI_HUMAN
Homo sapiens
DNA polymerase iota

PDB Structure

PDB 5KT2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
J.Biol.Chem.