CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.25 | Alpha Horseshoe |
|
1.25.40 | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
|
1.25.40.10 | Tetratricopeptide repeat domain |
Domain Context
CATH Clusters
| Superfamily | Tetratricopeptide repeat domain |
| Functional Family | N-lysine methyltransferase SMYD2 isoform X2 |
Enzyme Information
| 2.1.1.- |
Methyltransferases.
based on mapping to UniProt Q9NRG4
|
| 2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NRG4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|
UniProtKB Entries (1)
| Q9NRG4 |
SMYD2_HUMAN
Homo sapiens
N-lysine methyltransferase SMYD2
|
PDB Structure
| PDB | 5KJM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.
J. Med. Chem.
|