CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.103
L-threonine 3-dehydrogenase.
based on mapping to UniProt Q2T9E1
L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + NADH.
-!- Acts in concert with EC 2.3.1.29 in the degradation of threonine to glycine. -!- This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex. -!- In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.

UniProtKB Entries (1)

Q2T9E1
TDH_BURTA
Burkholderia thailandensis E264
L-threonine 3-dehydrogenase

PDB Structure

PDB 5KIA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of L-threonine 3-dehydrogenase from Burkholderia thailandensis
Abendroth, J., Lukacs, C.M., Lorimer, D.D., Edwards, T.E.
to be published