CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase eta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9Y253
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9Y253
POLH_HUMAN
Homo sapiens
DNA polymerase eta

PDB Structure

PDB 5KFK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Capture of a third Mg2+ is essential for catalyzing DNA synthesis.
Gao, Y., Yang, W.
Science