CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family

Enzyme Information

2.1.3.15
Acetyl-CoA carboxytransferase.
based on mapping to UniProt Q2FG38
[Biotin carboxyl-carrier protein]-N(6)-carboxybiotinyl-L-lysine + acetyl- CoA = [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine + malonyl- CoA.
-!- The enzyme catalyzes the transfer of a carboxyl group carried on a biotinylated biotin carboxyl carrier protein (BCCP) to acetyl-CoA, forming malonyl-CoA. -!- In some organisms this activity is part of a multi-domain polypeptide that includes the carrier protein and EC 6.3.4.14 (see EC 6.4.1.2). -!- Some enzymes can also carboxylate propanonyl-CoA and butanoyl-CoA (Cf. EC 6.4.1.3).

UniProtKB Entries (2)

Q2YTE0
ACCD_STAAB
Staphylococcus aureus RF122
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Q2FG38
ACCA_STAA3
Staphylococcus aureus subsp. aureus USA300
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

PDB Structure

PDB 5KDR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide B.
Silvers, M.A., Pakhomova, S., Neau, D.B., Silvers, W.C., Anzalone, N., Taylor, C.M., Waldrop, G.L.
Biochemistry