CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside phosphorylase domain
Functional Family Aminodeoxyfutalosine nucleosidase

Enzyme Information

3.2.2.9
Adenosylhomocysteine nucleosidase.
based on mapping to UniProt Q9ZMY2
S-adenosyl-L-homocysteine + H(2)O = S-(5-deoxy-D-ribos-5-yl)-L- homocysteine + adenine.
3.2.2.30
Aminodeoxyfutalosine nucleosidase.
based on mapping to UniProt Q9ZMY2
6-amino-6-deoxyfutalosine + H(2)O = dehypoxanthine futalosine + adenine.
-!- The enzyme, found in several bacterial species, catalyzes a step in a modified futalosine pathway for menaquinone biosynthesis. -!- While the enzyme from some organisms also has the activity of EC 3.2.2.9 the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine.

UniProtKB Entries (1)

Q9ZMY2
MQMTN_HELPJ
Helicobacter pylori J99
Aminodeoxyfutalosine nucleosidase

PDB Structure

PDB 5KB3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states.
Banco, M.T., Mishra, V., Ostermann, A., Schrader, T.E., Evans, G.B., Kovalevsky, A., Ronning, D.R.
Proc. Natl. Acad. Sci. U.S.A.