CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00523
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00523
SRC_CHICK
Gallus gallus
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 5K9I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.
Zhao, Q., Ouyang, X., Wan, X., Gajiwala, K.S., Kath, J.C., Jones, L.H., Burlingame, A.L., Taunton, J.
J. Am. Chem. Soc.