CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Acetolactate synthase large subunit

Enzyme Information

2.2.1.6
Acetolactate synthase.
based on mapping to UniProt P17597
2 pyruvate = 2-acetolactate + CO(2).
-!- The reaction shown is in the pathway of biosynthesis of valine. -!- The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. -!- Formerly EC 4.1.3.18.

UniProtKB Entries (1)

P17597
ILVB_ARATH
Arabidopsis thaliana
Acetolactate synthase, chloroplastic

PDB Structure

PDB 5K6R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families.
Garcia, M.D., Nouwens, A., Lonhienne, T.G., Guddat, L.W.
Proc. Natl. Acad. Sci. U.S.A.