CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Glycogen synthase kinase-3 beta

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49841
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26
[Tau protein] kinase.
based on mapping to UniProt P49841
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

P49841
GSK3B_HUMAN
Homo sapiens
Glycogen synthase kinase-3 beta

PDB Structure

PDB 5K5N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Liang, S.H., Chen, J.M., Normandin, M.D., Chang, J.S., Chang, G.C., Taylor, C.K., Trapa, P., Plummer, M.S., Para, K.S., Conn, E.L., Lopresti-Morrow, L., Lanyon, L.F., Cook, J.M., Richter, K.E., Nolan, C.E., Schachter, J.B., Janat, F., Che, Y., Shanmugasundaram, V., Lefker, B.A., Enerson, B.E., Livni, E., Wang, L., Guehl, N.J., Patnaik, D., Wagner, F.F., Perlis, R., Holson, E.B., Haggarty, S.J., El Fakhri, G., Kurumbail, R.G., Vasdev, N.
Angew.Chem.Int.Ed.Engl.