CATH Domain 5k5mA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.2840	Flavivirus RNA-directed RNA polymerase, thumb domain

Domain Context

CATH Clusters

Superfamily	Flavivirus RNA-directed RNA polymerase, thumb domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

A0A097PIE2_9FLAV

Dengue virus 2

Genome polyprotein

PDB Structure

PDB	5K5M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling. Lim, S.P., Noble, C.G., Seh, C.C., Soh, T.S., El Sahili, A., Chan, G.K., Lescar, J., Arora, R., Benson, T., Nilar, S., Manjunatha, U., Wan, K.F., Dong, H., Xie, X., Shi, P.Y., Yokokawa, F. Plos Pathog.