CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt C7C422
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

C7C422
BLAN1_KLEPN
Klebsiella pneumoniae
Metallo-beta-lactamase type 2

PDB Structure

PDB 5K4M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Enzyme evolvability is contingent on the initial sequence background
Baier, F., Hong, N.-S., Yang, G., Carr, P.D., Jackson, C., Tokuriki, N.
To Be Published