1 keywords

CATH Domain 5k4lA02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.150 DNA polymerase; domain 1
Homologous Superfamily 1.10.150.60 ARID DNA-binding domain

Domain Context

CATH Clusters

Superfamily ARID DNA-binding domain
Functional Family Putative lysine-specific demethylase 5b

Enzyme Information

1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt P29375

UniProtKB Entries (1)

P29375
KDM5A_HUMAN
Homo sapiens
Lysine-specific demethylase 5A

PDB Structure

PDB 5K4L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.
Labadie, S.S., Dragovich, P.S., Cummings, R.T., Deshmukh, G., Gustafson, A., Han, N., Harmange, J.C., Kiefer, J.R., Li, Y., Liang, J., Liederer, B.M., Liu, Y., Manieri, W., Mao, W., Murray, L., Ortwine, D.F., Trojer, P., VanderPorten, E., Vinogradova, M., Wen, L.
Bioorg.Med.Chem.Lett.