CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family protein tyrosine phosphatase type IVA 1

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q12974
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

Q12974
TP4A2_HUMAN
Homo sapiens
Protein tyrosine phosphatase type IVA 2

PDB Structure

PDB 5K25
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3.
Zhang, H., Kozlov, G., Li, X., Wu, H., Gulerez, I., Gehring, K.
Sci Rep