CATH Classification

Domain Context

CATH Clusters

Superfamily Isoleucyl-tRNA Synthetase; Domain 1
Functional Family

Enzyme Information

6.1.1.10
Methionine--tRNA ligase.
based on mapping to UniProt P59078
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

P59078
SYM_BRUSU
Brucella suis 1330
Methionine--tRNA ligase

PDB Structure

PDB 5K0S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Ojo, K.K., Ranade, R.M., Zhang, Z., Dranow, D.M., Myers, J.B., Choi, R., Nakazawa Hewitt, S., Edwards, T.E., Davies, D.R., Lorimer, D., Boyle, S.M., Barrett, L.K., Buckner, F.S., Fan, E., Van Voorhis, W.C.
Plos One