1 keywords

CATH Domain 5k0iA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.120 Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous Superfamily 1.20.120.550 Membrane associated eicosanoid/glutathione metabolism-like domain

Domain Context

CATH Clusters

Superfamily Membrane associated eicosanoid/glutathione metabolism-like domain
Functional Family Microsomal glutathione S-transferase 1

Enzyme Information

5.3.99.3
Prostaglandin-E synthase.
based on mapping to UniProt O14684
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

O14684
PTGES_HUMAN
Homo sapiens
Prostaglandin E synthase

PDB Structure

PDB 5K0I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Kuklish, S.L., Antonysamy, S., Bhattachar, S.N., Chandrasekhar, S., Fisher, M.J., Fretland, A.J., Gooding, K., Harvey, A., Hughes, N.E., Luz, J.G., Manninen, P.R., McGee, J.E., Navarro, A., Norman, B.H., Partridge, K.M., Quimby, S.J., Schiffler, M.A., Sloan, A.V., Warshawsky, A.M., York, J.S., Yu, X.P.
Bioorg.Med.Chem.Lett.