CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Carminomycin 4-O-methyltransferase DnrK

Enzyme Information

2.1.1.292
Carminomycin 4-O-methyltransferase.
based on mapping to UniProt Q06528
S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin.
-!- The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. -!- In vitro the enzyme from Streptomyces sp. C5 also catalyzes the 4-O- methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy- 13-deoxycarminomycin.

UniProtKB Entries (1)

Q06528
DNRK_STRPE
Streptomyces peucetius
Carminomycin 4-O-methyltransferase DnrK

PDB Structure

PDB 5JR3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 4-methylumbelliferone (to be published)
Wang, F., Johnson, B.R., Huber, T.D., Singh, S., Thorson, J.S., Phillips Jr., G.N.
To Be Published