CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1740.10
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt Q8IKG4
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

Q8IKG4
DXR_PLAF7
Plasmodium falciparum 3D7
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic

PDB Structure

PDB 5JO0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Sooriyaarachchi, S., Chofor, R., Risseeuw, M.D., Bergfors, T., Pouyez, J., Dowd, C.S., Maes, L., Wouters, J., Jones, T.A., Van Calenbergh, S., Mowbray, S.L.
Chemmedchem