CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P22455
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P22455
FGFR4_HUMAN
Homo sapiens
Fibroblast growth factor receptor 4

PDB Structure

PDB 5JKG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
Wu, D., Guo, M., Philips, M.A., Qu, L., Jiang, L., Li, J., Chen, X., Chen, Z., Chen, L., Chen, Y.
Plos One