CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Euchromatic histone-lysine N-methyltransferase 2

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q96KQ7
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-
Methyltransferases.
based on mapping to UniProt Q96KQ7

UniProtKB Entries (1)

P68431
H31_HUMAN
Homo sapiens
Histone H3.1

PDB Structure

PDB 5JHN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Jayaram, H., Hoelper, D., Jain, S.U., Cantone, N., Lundgren, S.M., Poy, F., Allis, C.D., Cummings, R., Bellon, S., Lewis, P.W.
Proc.Natl.Acad.Sci.USA