CATH Domain 5iw5A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.79	Nucleoside Triphosphate Pyrophosphohydrolase
	3.90.79.10	Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily	Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family	NADH pyrophosphatase

Enzyme Information

3.6.1.22

NAD(+) diphosphatase.

based on mapping to UniProt D6JHV3

NAD(H) + H(2)O = AMP + NMN(H).

-!- This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. -!- Also acts on other dinucleotides, including NADP(H), FAD(H(2)), and the thionicotinamide analogs of NAD(+) and NADP(+).

UniProtKB Entries (1)

D6JHV3

D6JHV3_ECOLX

Escherichia coli B354

NADH pyrophosphatase

PDB Structure

PDB	5IW5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and function of the bacterial decapping enzyme NudC Hofer, K., Li, S., Abele, F., Frindert, J., Schlotthauer, J., Grawenhoff, J., Du, J., Patel, D.J., Jaschke, A. Nat.Chem.Biol.