CATH Classification

Domain Context

CATH Clusters

Superfamily MutM-like, N-terminal
Functional Family Endonuclease 8-like 1

Enzyme Information

4.2.99.18
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt Q96FI4
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
3.2.2.-
Hydrolyzing N-glycosyl compounds.
based on mapping to UniProt Q96FI4

UniProtKB Entries (1)

Q96FI4
NEIL1_HUMAN
Homo sapiens
Endonuclease 8-like 1

PDB Structure

PDB 5ITY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair
Zhu, C., Lu, L., Zhang, J., Yue, Z., Song, J., Zong, S., Liu, M., Stovicek, O., Gao, Y.Q., Yi, C.
Proc.Natl.Acad.Sci.USA