1 keywords

CATH Domain 5is5A05

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1070 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5
Homologous Superfamily 1.10.1070.11 Phosphatidylinositol 3-/4-kinase, catalytic domain

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain
Functional Family Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O35904
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

UniProtKB Entries (1)

O35904
PK3CD_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PDB Structure

PDB 5IS5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
Hoegenauer, K., Soldermann, N., Stauffer, F., Furet, P., Graveleau, N., Smith, A.B., Hebach, C., Hollingworth, G.J., Lewis, I., Gutmann, S., Rummel, G., Knapp, M., Wolf, R.M., Blanz, J., Feifel, R., Burkhart, C., Zecri, F.
Acs Med.Chem.Lett.