CATH Classification

Domain Context

CATH Clusters

Superfamily Histone deacetylase domain
Functional Family Type-1 histone deacetylase 1

Enzyme Information
Histone deacetylase.
based on mapping to UniProt Q13547
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC

UniProtKB Entries (1)

Homo sapiens
Metastasis-associated protein MTA1

PDB Structure

External Links
Primary Citation
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.
Watson, P.J., Millard, C.J., Riley, A.M., Robertson, N.S., Wright, L.C., Godage, H.Y., Cowley, S.M., Jamieson, A.G., Potter, B.V., Schwabe, J.W.
Nat Commun