CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.128 |
(RS)-norcoclaurine 6-O-methyltransferase.
based on mapping to UniProt Q5C9L7
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine.
-!- The enzyme will also catalyze the 6-O-methylation of (RS)- norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.
|
UniProtKB Entries (1)
| Q5C9L7 |
6OMT_THLFG
Thalictrum flavum subsp. glaucum
(RS)-norcoclaurine 6-O-methyltransferase
|
PDB Structure
| PDB | 5ICC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of norcoclaurine-6-O-methyltransferase, a key rate-limiting step in the synthesis of benzylisoquinoline alkaloids.
Plant J.
|