CATH Classification

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Enzyme Information

1.13.11.54
Acireductone dioxygenase (Fe(2+)-requiring).
based on mapping to UniProt Q99JT9
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2- oxobutanoate + formate.
-!- If Ni(2+) is bound instead of Fe(2+), the reaction catalyzed by EC 1.13.11.53 occurs instead. -!- The enzyme from Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC 8724 is involved in the methionine salvage pathway.

UniProtKB Entries (1)

Q99JT9
MTND_MOUSE
Mus musculus
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

PDB Structure

PDB 5I93
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.
Deshpande, A.R., Wagenpfeil, K., Pochapsky, T.C., Petsko, G.A., Ringe, D.
Biochemistry