CATH Classification

Domain Context

CATH Clusters

Superfamily Diphtheria Toxin, domain 1
Functional Family

Enzyme Information

2.4.2.36
NAD(+)--diphthamide ADP-ribosyltransferase.
based on mapping to UniProt Q6NK15
NAD(+) + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2].
-!- Dihtheria toxin and some other bacterial toxins catalyze this reaction, which inactivates translation elongation factor 2 (EF2). -!- The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. -!- Cf. EC 2.4.2.31. -!- The relevant histidine of EF2 is His(715) in mammals, His(699) in yeast and His(600) in Pyrococcus horikoshii.

UniProtKB Entries (1)

Q6NK15
Q6NK15_CORDI
Corynebacterium diphtheriae NCTC 13129
Diphtheria toxin

PDB Structure

PDB 5I82
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
First Crystal Structure of E.coli Based Recombinant Diphtheria Toxin Mutant CRM197.
Minasov, G., Shuvalova, L., Mishra, R.P.N., Goel, A., Dubrovska, I., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
To Be Published