CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5
Dipeptidyl-peptidase IV.
based on mapping to UniProt P27487
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487
DPP4_HUMAN
Homo sapiens
Dipeptidyl peptidase 4

PDB Structure

PDB 5I7U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.
Wu, W.L., Hao, J., Domalski, M., Burnett, D.A., Pissarnitski, D., Zhao, Z., Stamford, A., Scapin, G., Gao, Y.D., Soriano, A., Kelly, T.M., Yao, Z., Powles, M.A., Chen, S., Mei, H., Hwa, J.
Acs Med.Chem.Lett.