CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt O60674
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O60674
JAK2_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK2

PDB Structure

PDB 5I4N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 alpha C helix.
Leroy, E., Dusa, A., Colau, D., Motamedi, A., Cahu, X., Mouton, C., Huang, L.J., Shiau, A.K., Constantinescu, S.N.
Biochem.J.