CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Coagulation factor XI

Enzyme Information

3.4.21.27
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P01042
KNG1_HUMAN
Homo sapiens
Kininogen-1

PDB Structure

PDB 5I25
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Wong, S.S., stergaard, S., Hall, G., Li, C., Williams, P.M., Stennicke, H., Emsley, J.
Blood