CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family

Enzyme Information
Type I protein arginine methyltransferase.
based on mapping to UniProt Q96LA8
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L- homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
-!- This eukaryotic enzyme catalyzes the sequential dimethylation of one of the terminal guanidino nitrogen atoms in arginine residues, resulting in formation of asymmetric dimethylarginine residues. -!- Some forms (e.g. PRMT1) have a very wide substrate specificity, while others (e.g. PRMT4 and PRMT6) are rather specific. -!- The enzyme has a preference for methylating arginine residues that are flanked by one or more glycine residues. -!- PRMT1 is responsible for the bulk (about 85%) of total protein arginine methylation activity in mammalian cells. -!- Cf. EC, EC and EC -!- Formerly EC, EC, EC and EC

UniProtKB Entries (1)

Homo sapiens
Protein arginine N-methyltransferase 6

PDB Structure

External Links
Primary Citation
Structural basis of arginine asymmetrical dimethylation by PRMT6.
Wu, H., Zheng, W., Eram, M.S., Vhuiyan, M., Dong, A., Zeng, H., He, H., Brown, P., Frankel, A., Vedadi, M., Luo, M., Min, J.
Biochem. J.