CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidylprolyl isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q4WLV6
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q4WLV6
FKB1A_ASPFU
Aspergillus fumigatus Af293
FK506-binding protein 1A

PDB Structure

PDB 5HWB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Tonthat, N.K., Juvvadi, P.R., Zhang, H., Lee, S.C., Venters, R., Spicer, L., Steinbach, W.J., Heitman, J., Schumacher, M.A.
Mbio