CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cyclin-dependent kinase 8 isoform X1

Enzyme Information

2.7.11.23
[RNA-polymerase]-subunit kinase.
based on mapping to UniProt P49336
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.
2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P49336
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P49336
CDK8_HUMAN
Homo sapiens
Cyclin-dependent kinase 8

PDB Structure

PDB 5HVY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.
Bergeron, P., Koehler, M.F., Blackwood, E.M., Bowman, K., Clark, K., Firestein, R., Kiefer, J.R., Maskos, K., McCleland, M.L., Orren, L., Ramaswamy, S., Salphati, L., Schmidt, S., Schneider, E.V., Wu, J., Beresini, M.
Acs Med.Chem.Lett.