CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Rho-associated protein kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q13464
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13464
ROCK1_HUMAN
Homo sapiens
Rho-associated protein kinase 1

PDB Structure

PDB 5HVU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.
Gao, H., Marhefka, C., Jacobs, M.D., Cao, J., Bandarage, U.K., Green, J.
Bioorg. Med. Chem. Lett.