CATH Classification

Domain Context

CATH Clusters

Superfamily 1.25.40.970
Functional Family Histone-lysine N-methyltransferase SMYD3

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9H7B4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9H7B4
SMYD3_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase SMYD3

PDB Structure

PDB 5HQ8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.
Van Aller, G.S., Graves, A.P., Elkins, P.A., Bonnette, W.G., McDevitt, P.J., Zappacosta, F., Annan, R.S., Dean, T.W., Su, D.S., Carpenter, C.L., Mohammad, H.P., Kruger, R.G.
Structure