CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Putative Cyclin-dependent kinase 1

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P06493
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.
2.7.11.23
[RNA-polymerase]-subunit kinase.
based on mapping to UniProt P06493
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.

UniProtKB Entries (1)

P33552
CKS2_HUMAN
Homo sapiens
Cyclin-dependent kinases regulatory subunit 2

PDB Structure

PDB 5HQ0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Brown, N.R., Korolchuk, S., Martin, M.P., Stanley, W.A., Moukhametzianov, R., Noble, M.E., Endicott, J.A.
Nat Commun