CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q13882
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q13882
PTK6_HUMAN
Homo sapiens
Protein-tyrosine kinase 6

PDB Structure

PDB 5H2U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution
Thakur, M.K., Birudukota, S., Swaminathan, S., Battula, S.K., Vadivelu, S., Tyagi, R., Gosu, R.
Biochem. Biophys. Res. Commun.