CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.79 | Nucleoside Triphosphate Pyrophosphohydrolase |
|
3.90.79.10 | Nucleoside Triphosphate Pyrophosphohydrolase |
Domain Context
CATH Clusters
| Superfamily | Nucleoside Triphosphate Pyrophosphohydrolase |
| Functional Family | Nucleotide triphosphate diphosphatase NUDT15 |
Enzyme Information
| 3.6.1.55 |
8-oxo-dGTP diphosphatase.
based on mapping to UniProt Q9CA40
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).
|
| 3.6.1.67 |
Dihydroneopterin triphosphate diphosphatase.
based on mapping to UniProt Q9CA40
7,8-dihydroneopterin 3'-triphosphate + H(2)O = 7,8-dihydroneopterin 3'-phosphate + diphosphate.
-!- The enzyme participates in a folate biosynthesis pathway, which is found in bacteria, fungi, and plants. -!- Formerly EC 3.6.1.n4.
|
| 3.6.1.22 |
NAD(+) diphosphatase.
based on mapping to UniProt Q9CA40
NAD(H) + H(2)O = AMP + NMN(H).
-!- This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. -!- Also acts on other dinucleotides, including NADP(H), FAD(H(2)), and the thionicotinamide analogs of NAD(+) and NADP(+).
|
UniProtKB Entries (1)
| Q9CA40 |
NUDT1_ARATH
Arabidopsis thaliana
Nudix hydrolase 1
|
PDB Structure
| PDB | 5GP0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis.
Mol Plant
|