CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.40.20
Functional Family Transitional endoplasmic reticulum ATPase

Enzyme Information

3.6.4.6
Vesicle-fusing ATPase.
based on mapping to UniProt P55072
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

P55072
TERA_HUMAN
Homo sapiens
Transitional endoplasmic reticulum ATPase

PDB Structure

PDB 5FTK
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition
Banerjee, S., Bartesaghi, A., Merk, A., Rao, P., Bulfer, S.L., Yan, Y., Green, N., Mroczkowski, B., Neitz, R.J., Wipf, P., Falconieri, V., Deshaies, R.J., Milne, J.L.S., Huryn, D., Arkin, M., Subramaniam, S.
Science