CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P11362
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P11362
FGFR1_HUMAN
Homo sapiens
Fibroblast growth factor receptor 1

PDB Structure

PDB 5FLF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Landscape of Activating Cancer Mutations in Fgfr Kinases and Their Differential Responses to Inhibitors in Clinical Use.
Patani, H., Bunney, T.D., Thiyagarajan, N., Norman, R.A., Ogg, D., Breed, J., Ashford, P., Potterton, A., Edwards, M., Williams, S.V., Thomson, G.S., Pang, C.S., Knowles, M.A., Breeze, A.L., Orengo, C., Phillips, C., Katan, M.
Oncotarget