CATH Classification

Domain Context

CATH Clusters

Superfamily Haem peroxidase domain superfamily, animal type
Functional Family Myeloperoxidase

Enzyme Information

1.11.2.2
Myeloperoxidase.
based on mapping to UniProt P05164
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O.
-!- Is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. -!- It differs from EC 1.11.1.10 in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). -!- Hypochlorite in turn forms a number of antimicrobial products (Cl(2), chloramines, hydroxyl radical, singlet oxygen). -!- MPO also oxidizes bromide, iodide and thiocyanate. -!- In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.

UniProtKB Entries (1)

P05164
PERM_HUMAN
Homo sapiens
Myeloperoxidase

PDB Structure

PDB 5FIW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Myeloperoxidase at 1.7 Angstroms Resolution
Bonnefond, L., Cavarelli, J.
To be Published