CATH Classification

Domain Context

CATH Clusters

Superfamily TPP-binding domain
Functional Family Acetolactate synthase

Enzyme Information

2.2.1.6
Acetolactate synthase.
based on mapping to UniProt P07342
2 pyruvate = 2-acetolactate + CO(2).
-!- The reaction shown is in the pathway of biosynthesis of valine. -!- The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. -!- Formerly EC 4.1.3.18.

UniProtKB Entries (1)

P07342
ILVB_YEAST
Saccharomyces cerevisiae S288C
Acetolactate synthase catalytic subunit, mitochondrial

PDB Structure

PDB 5FEM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase.
Lonhienne, T., Nouwens, A., Williams, C.M., Fraser, J.A., Lee, Y.T., West, N.P., Guddat, L.W.
Angew.Chem.Int.Ed.Engl.